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KMID : 0869620140310061092
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Journal of Korean Society of Hospital Pharmacists
2014 Volume.31 No. 6 p.1092 ~ p.1096
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Analysis of the Loss Amounts of Hygroscopic Drug in Powder form in Dispensing, Storage and Process Improvement to Decrease Loss
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Kim Mi-Rang
Kim Min-Sun
Lee Yeon-Joo
Kim Seoung-Lan
Na Yang-Sook
Gwak Hye-Sun
Kim Jae-Yeun
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Abstract
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Tablet medications have been dispensed in powder form for patients who are unable to swallow pills whether the pills have a hygroscopic nature or not. Powder form dispensing procedures consist of crushing, straining, distributing and packaging. During the processing, there is a high chance of losing some of the drug. Especially, it is predicted that a significant amount of hygroscopic medication could be lost when dispensed in powder form. This study aimed to analyze the loss amounts, to compare the loss amounts between hygroscopic medication and normal medication and to suggest methods to decrease loss. Normal tablets and film-coated tablets as control medication as well as 7 hygroscopic tablets were compared. To adjust for bias against the percentage of loss being inversely proportional to the weight of the tablets, we analyzed the loss amounts after preparing various weights of powder form with control tablets. The average loss was 7.5% vs 0.5, 6.6% (hygroscopic tablets vs non film and film-coating tablets) during grinding and straining. The average loss at distribution was 7.3% vs 4.3, 4.2%. We suggest skipping the straining process to decrease loss during grinding. Without straining, the solving times with the hygroscopic drug powders were 60.5 (25±1℃) and 42.5 (35±1℃) seconds. The increased amount of hygroscopic powder in room air due to moisture absorbance was compared to control drug: 4.56% vs 2.63% (control), 3.03% vs 1.87% without or with silica gel. The amount of hygroscopic drugs lost with processing into power form was greater than for normal drugs. A particularly large gap was observed during grinding and straining. We suggest avoiding the straining process and encasing hygroscopic drug powders in silica gel.
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KEYWORD
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Powder, Hygroscopic drug, Dispensing powder
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